So why would you like are all non albicans candida?

那么，为什么你会想知道所有非念珠菌念珠菌呢？

The use of allergenic extracts of candida albicans for immunotherapy or provocation neutralization.

使念珠菌过敏原提取物进行免疫疗法或激发-中和试验。

And so are all candida albicans individual, you know, cells or whatever, capable of this transformation?

因此， 所有念珠菌个体，即那些细胞或诸如此类生物， 是否都具备这转变能力呢？

Because Albicans is a commensal, but these don't seem to be commensals.

因为念珠菌是一共生菌，但这些似乎不是共生菌。

We see resistance in C. auris, some strains, to almost all of the antifungals that we use.

我们发现，在某些菌株中，念珠菌对几乎所有我们使抗真菌药物都产生了耐药。

But for most of this episode, especially for the pathogenicity part of things, I'm gonna focus on Candida albicans.

但在本节大部分内容中， 特别是关于致部分，我将重点关注念珠菌。

Yeah, I have the exact same timeline about 10 years ago, I like maybe one resistant Candida albicans infection a year, like maybe two.

是，我大约十年前有过同样经历，我可能每年会有一两次抗真菌耐药念珠菌感染。

And when the balance within the vagina is disrupted— like the pH increases or there are fewer microbes to compete with— Candida albicans may assume their disease-causing forms.

当阴道内平衡被破坏时— — 比如 pH 值升高或与之竞争微生物减少— —念珠菌可能会呈现出它们致形式。

And I think that's also part of why they're saying call everything non-Albicans because it's like they've been renaming some things, which is important, but also gets confusing.

我认为这也是为什么他们建议将所有非念珠菌菌统称为非念珠菌原因之一， 因为这就像他们在重新命名一些事物，虽然这很重要， 但也容易造成混淆。

So the kind of most notable ones, and there are more than these two, but kind of the most notable ones are Candida auris, and we'll talk more about that later.

因此， 最引人注目几， 虽然不止这两，但尤其值得一提是念珠菌，我们稍后会详细讨论它。

Probably the first case was maybe a decade ago, but now what we're seeing almost every week or so in our program is women with Candida albicans infections that are very resistant to antifungals.

可能第一例是在十年前左右，但现在我们在项目中几乎每周都能看到患有对抗真菌药物非常耐药念珠菌感染女。