Because I want to talk about down-regulating PDE5.

为我想谈谈下调磷酸二酯酶5。

PDF5 inhibitors would inhibit the breakdown, but there's nothing to inhibit the breakdown of.

磷酸二酯酶5制制其分解，但并没有什么可以制其分解的物质。

Nitric oxide is kind of difficult too, because a lot of things that decrease it, if you take it long enough, your body will become better at making it and actually make less phosphodiesterase enzymes.

一氧化氮也颇为棘手，为许多降低其水平的素，若长期作用， 使身体更擅长制造它， 反而减少了磷酸二酯酶的生成。

This is probably one of the number one reasons when you look at the different conditions, health conditions, comorbidities, when people don't respond to PDF5 inhibitors.

这可能是当你查看不同况和共病时，人们不响应磷酸二酯酶5制的首要原之一。

I just posted this article about how to deal with PDE5 inhibitors, non-responsiveness.

我刚发了一篇文章，讲的是如何应对磷酸二酯酶5制的无反应问题。

So, berberine will have almost no effect on the on the protein level of PDE5.

所以，小檗碱几乎不影响磷酸二酯酶5的蛋白水平。

I mean, they have hypothesis, but they're not sure why exactly that's happening because it doesn't have the direct effect on PDE5.

我的意思是，他们提出了假设，但并不确定为何发生这种情况，为这并没有直接作用于磷酸二酯酶5（PDE5）。