The version she has includes a gene that is resistant to colistin.

这种细菌中有一种基因可以抵御菌素。

So, in this case, Klebsiella can be treated with colistin, tigecycline, or fosfomycin.

这种情况下，可以应菌素、替加环素或者磷霉素来治疗。

So we're talking about things that are is different from us as like a a sponge or even more different from us than a sponge, like something like a slime mold versus us.

所以我们谈论的是与我们不同的东西，比如海绵——甚至其差异比海绵跟我们的差异还大的东西，譬如菌。

For some infected patients, their last hope is the antibiotic colistin, a toxic substance with potential side effects that include kidney and brain damage.

对一些受感染的病人来，他们最后的希望是抗生素菌素，这是一种有潜在副作的有毒物质，包括肾脏和大脑损伤。

It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.

肺炎克雷伯杆菌也是一种重耐药菌，如果产生β-内酰胺酶，可以头孢菌素、氨基糖苷、氟喹以及碳青霉烯药物治疗；如果产生ESBL，可以只应碳青霉烯进行治疗；如果产生碳青霉烯酶，则应菌素、替加环素或磷霉素进行治疗。

Tom Frieden is the head of the U.S. Centers for Disease Control and Prevention. He says this new bug is resistant to every antibiotic available, including colistin.

美国疾病控制中心的主任汤姆·福里登称，该细菌可以抵御包括菌素在内的任何医抗生素。

Colistin is used only as a last measure, as the drug can cause organ damage.

由于菌素会对人体器官造成伤害，因此不到万不得已，不会使。

He says the powerful antibiotic Colistin has become an important last line of defense.

他，强效抗生素菌素已成为重要的最后一道防线。

Studying slime mold is, it's probably one of the weirdest organisms I've worked with.

- 研究菌是，它可能是我接触过的最奇怪的生物之一。

It’s a strain of E. Coli bacteria that’s resistant to colistin, one of the strongest antibiotics we have.

这是一种对菌素具有抗药性的大肠杆菌菌株，菌素是我们拥有的最强效的抗生素之一。

Now, even Colistin is losing its power against highly resistant bacteria called " superbugs."

现在，即使是菌素也失去了对抗被称为“超级细菌”的高度耐药细菌的能力。

The mutation makes the bug resistant to colistin , an antibiotic that’s considered the last line of defense.

这种突变使细菌对菌素产生了抗药性，而菌素被认为是最后一道防线的抗生素。

What they found is that the slime molds actually build networks that are pretty close to optimal.

- 他们发现，菌实际上建立了非常接近最佳的网络。

And combining the sugars with an antibacterial protein called polymyxin B, found in human saliva and potentially breast milk, made it better at poking holes in bacterial cell membranes to fight off infection.

并且将这些糖与一种名为菌素B的抗菌蛋白结合使，这种蛋白存在于人唾液中， 可能也存在于母乳中， 使其更擅长在细菌细胞膜上穿孔以抵抗感染。