Symptoms of tuberous sclerosis are often related to the hamartomas in the brain which cause problems like seizures, learning difficulties, and cognitive deficits.
She also had chronic neutropenia and later developed tender, hyperpigmented nodules on her shins, diagnosed as erythema induratum, with evidence of tuberculosis infection.
And there's one more problem: each individual nodule creates a temporal instability that raises the chances the portal might collapse as you go through it.
The British Thoracic Society guidelines for pulmonary nodules recommend the Herder risk model for predicting malignancy in solid pulmonary nodules after PET-CT.