The mast cells, aren't considered PMNs because their nucleus is round.

肥大不被认为是PMNs，由于其核呈圆形。

Finally, there are the mast cells which are also non-phagocytic and they're involved in asthma and allergic responses.

最后，还有肥大，它们也没有吞噬作用，还参与了哮喘和过敏反应。

Well, it could be mast cell leukemia.

也可能是肥大病。

If there are symptoms, antihistamine medications can be used to suppress the effect of mast cell degranulation.

如果出现相应临床症状，抗组胺药可以被用来抑制肥大脱颗粒效应。

The food proteins get noticed by IgE, which activates the mast cells.

食物中蛋质会被 IgE 注意到，从而激活肥大。

We also know that, for example, dogs with short hair can be more prone to developing something called a mast cell tumor.

我们还知道，例如，毛发短狗可能更容易患肥大肿瘤。

The IgE-primed mast cells release their histamine, which causes nearby capillaries to dilate - flooding the facial tissues with fluid.

致敏肥大释放组胺通过增加周围毛管渗透性，最终导致面部组织水肿。

It's believed that these rashes appear due to a release of histamine from immune cells in the skin called mast cells.

据信，这些皮疹出现是由于免疫释放组胺所致在皮肤中称为肥大。

Because the eyes and nose are portals of entry for infections, there are lots of mast cells around those areas for extra protection.

由于眼睛和鼻子是外来性感染侵入机体主要通道，肥大在这些区域大量聚集来加强防护。

Those IgE antibodies get released into the bloodstream and bind to mast cells, which are immune cells in the tissue that carry within themselves a load histamine.

IgE型抗体在被释放入后，与组织中免疫肥大相结合，而这些肥大储存着大量生物活性物质组胺。

First they activate a part of the immune system called a mast cell, which then expels a lot of chemicals, like histamines.

首先，它们激活称为肥大免疫系统一部分， 然后排出大量化学物质，如组胺。

For example, IL-4 leads the production of IgE antibodies which coat mast cells and stimulate them to release granules containing things like histamines, leukotrienes and prostaglandins.

例如，IL-4导致了IgE抗体产生，覆盖在肥大表面，并刺激它们释放含有像组胺、三烯和前列腺素等物质颗粒。

The histamine causes blood capillaries to dilate and become leaky which brings more fluid and immune cells to the area where the mast cells are located.

组胺能使毛管通透性增加，进而促进更多体液和免疫渗漏到肥大所在处。

In tissues like the gut, the skin, and the respiratory system, the antibody called immunoglobulin E, or IgE, binds to white blood cells called mast cells.

在肠道、皮肤和呼吸系统等组织中，称为免疫球蛋 E 或 IgE 抗体与称为肥大结合。

Those cytokines start the inflammatory process by making blood vessels leaky and attracting nearby eosinophils, basophils, and mast cells, which release their own cytokines and granules amplifying the inflammation.

这些因子将启动炎症过程：通过使管渗漏并吸引附近嗜酸性粒、嗜碱性粒和肥大；这些集结释放各自因子和颗粒，放大炎症反应。

Once bound by IgE the mast cells are " primed" , meaning if pollen enters the body again in the future, those mast cells degranulate and release their histamine into the local tissue.

肥大与IgE型抗体结合后进入致敏状态，当花粉再次侵入机体时，肥大将脱颗粒并将组胺释放到周围组织。

Airborne allergens like pollen, dust, animal hair, or mold spores cause mast cells in the tissues to release histamine, causing the eyes and nose to become inflamed and watery.

花粉、尘土、动物毛发、霉菌孢子等空气传播过敏原通过促进组织中肥大释放组胺，最终导致眼睛和鼻子炎症和水肿。

Last year, the FDA approved Rydapt, a mast cell disorder and leukemia drug, and the Centers for Medicare and Medicaid Services approved limited reimbursements for its rare-blood-cancer drug, Kymriah, which runs $475,000 for a course of a treatment.

去年，FDA批准了Rydapt这种治疗肥大紊乱和病药物，医疗保险和医疗补助服务中心也批准了对其罕见癌药物Kymriah发放一定补助申请，而这种药物一个疗程费用就高达47.5万美元。