The mast cells, aren't considered PMNs because their nucleus is round.

肥大细胞不被认为是PMNs，由于其细胞核呈圆形。

If there are symptoms, antihistamine medications can be used to suppress the effect of mast cell degranulation.

如果出现相应的临床症状，抗组胺药可以被用来抑制肥大细胞的脱颗粒效应。

Finally, there are the mast cells which are also non-phagocytic and they're involved in asthma and allergic responses.

最后，还有肥大细胞，它们也没有吞噬作用，还参与了哮喘和过敏反应。

The food proteins get noticed by IgE, which activates the mast cells.

食物蛋白质会被免疫球蛋白E识别，从而激活肥大细胞。

Well, it could be mast cell leukemia.

也可能是肥大细胞白血病。

The MCAS, mass cell activation syndrome.

我现的诊断是肥大细胞活化综合征。

We also know that, for example, dogs with short hair can be more prone to developing something called a mast cell tumor.

我们还知道，例如，毛发短的狗可能更容易患肥大细胞肿瘤。

Well, it could be mast-cell leukemia.

威尔逊: 嗯, 可能是肥大细胞白血病。

The IgE-primed mast cells release their histamine, which causes nearby capillaries to dilate - flooding the facial tissues with fluid.

致敏肥大细胞释放的组胺通过增加周围毛细血管的渗透性，最终导致面部组织的充血水肿。

It's believed that these rashes appear due to a release of histamine from immune cells in the skin called mast cells.

据信，这些皮疹的出现是由于免疫细胞释放组胺所致皮肤中称为肥大细胞。

First they activate a part of the immune system called a mast cell, which then expels a lot of chemicals, like histamines.

首先，它们激活称为肥大细胞的免疫系统的部分， 然后排出大量化学物质，如组胺。

Because the eyes and nose are portals of entry for infections, there are lots of mast cells around those areas for extra protection.

由于眼睛和鼻子是外来性感染侵入机体的主要通道，肥大细胞这些区域大量聚集来加强防护。

For example, IL-4 leads the production of IgE antibodies which coat mast cells and stimulate them to release granules containing things like histamines, leukotrienes and prostaglandins.

例如，IL-4导致了IgE抗体的产，覆盖肥大细胞表面，并刺激它们释放含有像组胺、白三烯和前列腺素等物质的颗粒。

Those IgE antibodies get released into the bloodstream and bind to mast cells, which are immune cells in the tissue that carry within themselves a load histamine.

IgE型抗体被释放入血后，与组织中的免疫细胞肥大细胞相结合，而这些肥大细胞储存着大量的物活性物质组胺。

The histamine causes blood capillaries to dilate and become leaky which brings more fluid and immune cells to the area where the mast cells are located.

组胺能使毛细血管的通透性增加，进而促进更多的体液和免疫细胞渗漏到肥大细胞所处。

Those cytokines start the inflammatory process by making blood vessels leaky and attracting nearby eosinophils, basophils, and mast cells, which release their own cytokines and granules amplifying the inflammation.

这些细胞因子将启动炎症过程：通过使血管渗漏并吸引附近的嗜酸性粒细胞、嗜碱性粒细胞和肥大细胞；这些集结的细胞释放各自的细胞因子和颗粒，放大炎症反应。

In tissues like the gut, the skin, and the respiratory system, the antibody called immunoglobulin E, or IgE, binds to white blood cells called mast cells.

肠道、皮肤和呼吸系统这样的组织中，种名为免疫球蛋白E或IgE的抗体与称为肥大细胞的白血球结合。

Airborne allergens like pollen, dust, animal hair, or mold spores cause mast cells in the tissues to release histamine, causing the eyes and nose to become inflamed and watery.

花粉、尘土、动物毛发、霉菌孢子等空气传播的过敏原通过促进组织中的肥大细胞释放组胺，最终导致眼睛和鼻子的炎症和水肿。

Once bound by IgE the mast cells are " primed" , meaning if pollen enters the body again in the future, those mast cells degranulate and release their histamine into the local tissue.

肥大细胞与IgE型抗体结合后进入致敏状态，当花粉再次侵入机体时，肥大细胞将脱颗粒并将组胺释放到周围组织。

Last year, the FDA approved Rydapt, a mast cell disorder and leukemia drug, and the Centers for Medicare and Medicaid Services approved limited reimbursements for its rare-blood-cancer drug, Kymriah, which runs $475,000 for a course of a treatment.

去年，FDA批准了Rydapt这种治疗肥大细胞紊乱和白血病的药物，疗保险和疗补助服务中心也批准了对其罕见血癌药物Kymriah发放定补助的申请，而这种药物个疗程的费用就高达47.5万美元。