Phenoxyacetophenone could be prepared from potassium phenolate and m bromoacetophenone via Ullmann reaction catalyzed by copper acetate in high yields.
The primary synthetic methods of 4-hydroxycoumarin was reviewed starting from phenol, 2-acetylsalicylic acid, methyl salicylate, and o-hydroxyacetophenone respectively.
P-hydroxyacetophenone combined with methyl chloroacetate can get a new acetonate.This new acetonate combined with another compound-ethanolamine and get a new schiff base.
Firstly, p-methylacetophenone was obtained in the presence of alchlor as the catalyst, and the optimum condition was 4:1:2 in molar ratio for toluene, acetic anhydride and alchlor with yield of 86.2%.
But when researchers paired the orange-cherry-almondy scent of the chemical acetophenone with a painful electric shock, lab rats quickly learned to fear it.