Since science is heavily dependent on empirical observation for data, the Cartesian sensitivity to epistemological questions has dramatically enhanced the sophistication of human perception.
Buddhism is the only genuinely positive religion to be encountered in history, and this applies even to its epistemology (which is a strict phenomenalism).
There is the epistemological knowledge side of things and then there is the, he doesn't, it's not even emotional, it's just like the organic side of things.