There, it triggers the release of adrenocorticotropic hormone, or ACTH.

在那里，它触发促肾上腺皮质激素或促肾上腺皮质激素的释放。

Corticosteroid therapy with prednisolone and adrenocorticotropic hormone, or ACTH, can help control seizures in some infants.

用强的松龙、促肾上腺皮质激素（ACTH）等的皮质类固醇疗法可以帮助控制一些婴儿的癫痫发作。

As before, the excess cortisol provides negative feedback to the hypothalamus and pituitary gland, suppressing CRH and ACTH production.

像之前一样，过多的皮质醇会导致下丘脑和脑下垂体的负反馈，抑制CRH和ACTH的产。

Like there's some In a medical setting, they will test your cortisol response to ACTH.

像在医疗环境，他们会测试你对促肾上腺皮质激素的皮质醇反应。

So, ACTH is the precursor hormone from the pituitary that stimulates the adrenals to release cortisol.

因此，促肾上腺皮质激素（ACTH）是由垂体分泌的前体激素，它能刺激肾上腺释放皮质醇。

If the ACTH level is high, the next step is to give an injection of a high dose of dexamethasone.

如果ACTH水平过高，下一步则需要注射高剂量地塞米松。

The ACTH travels — again through the bloodstream — to the adrenal cortices of the adrenal glands on top of your kidneys.

促肾上腺皮质激素再次通过血液到达肾脏顶部肾上腺的肾上腺皮质。

But it is what regulates with ACH and ACTH, the amount of cortisol you produce, as well as epinephrine.

但它正是通过ACH和ACTH来调控你产的皮质醇量，以及肾上腺素。

ACTH, then, travels to the pair of adrenal glands, on top of each kidney, where it specifically targets cells in the adrenal cortex.

ACTH之后被运输到位于两个肾上方的肾上腺，在此专门针对肾上腺皮质细胞。

The most common reason for that is excess ACTH.

最常见的原因是过多的ACTH。

Unlike pituitary adenomas, ectopic sites of ACTH productions typically don't respond even to high doses of dexamethasone, and the serum cortisol remains high.

和垂体腺瘤不同，异位ACTH综合征一般对高剂量地塞米松没有反应，血清皮质醇还是会很高。

This causes a decrease in CRH and ACTH, which in turn, shuts down cortisol production from the zona fasciculata.

这会降低CRH和ACTH，反过来阻止束状带制造皮质醇。

Instead, the pituitary adenoma simply grows in size and secretes too much ACTH.

相反，垂体腺瘤只会增大，并分泌过多的ACTH。

If that test is positive, the next step is to determine the exact cause of endogenous cortisol production, and ACTH plasma levels can be checked.

如果测试结果为阳性，那下一步是探查内源性皮质醇失常的原因，可以检查血清促肾上腺皮质激素水平。

The ACTH specifically stimulates cells in this zone to secrete cortisol, which belongs to a class of steroids, or lipid-soluble hormones, called glucocorticoids.

ACTH主要刺激这一带的细胞释放皮质醇，属于糖皮质激素，是脂溶性激素类固醇的一种。

In some cases, Cushing syndrome results from a pituitary adenoma making excess ACTH, and in those situations it's called Cushing disease.

在某些病例，库欣综合征是由垂体腺瘤制造过多促肾上腺皮质激素导致的；在这种情况下，它被称作库欣病。

The excess ACTH overstimulates zona fasciculata of both adrenal glands, which grow larger and secrete excess cortisol.

过多的ACTH会过度刺激两个肾上腺的束状带，使其增大并分泌过多的皮质醇。

When the ACTH binds to receptors on cells in an adrenal cortex, it triggers the release of a frenzy of different freak-out compounds known as glucocorticoid and mineralcorticoid hormones.

当促肾上腺皮质激素与肾上腺皮质细胞上的受体结合时，它会引发不同反常化合物的疯狂释放，这些化合物被称为糖皮质激素和矿物质皮质激素。

With less ACTH floating around, the zona fasciculata gets less stimulation to make cortisol, and eventually, cortisol levels go back down to the normal range again.

随着ACTH减少，束状带受刺激产皮质醇减少，最后，皮质醇水平降低到正常范围内。

Alternatively, medications such as adrenal steroid inhibitors, like ketoconazole and metyrapone can be helpful - especially for cases of ectopic ACTH production or adrenal carcinomas that have already spread.

另一种方法，像肾上腺类固醇成抑制剂药物，比如酮康唑和甲吡酮，也会有帮助，尤其是在异位ACTH综合征或已扩散的肾上腺癌。