As well as forays into probability and game theory, he explains dice rolls in Monopoly using Markov chains; the torus-shaped playing field of video games like Spacewar!
Taken orally its LD50 is about 20 milligrams per kilogram of bodyweight, about 8 castor beans worth of the poison, but if it's injected, like the way Markov got it, it's just 1 tiny microgram per kilogram.
So what can we do? Well, it turns out we can do a thing which is called dependent sampling, and the most predominant method of doing dependent sampling is via markov chain, monte Carlo.