SIRT1 depends on a molecule called NAD (Nicotinamide adenine dinucleotide), and NAD, in turn, depends on the substance called NMN.

SIRT1的合成取决于一种叫NAD（辅酶）的分子，而NAD的合成则取决于一种叫NMN的物质。

Does increasing intracellular NAD matter when the system is so tightly regulated?

在系统如此严密调控的情况下，增加细胞内NAD真的重要吗？

And now for my discussion about NAD and longevity with Dr. Peter Attia.

现在我将与彼得·阿提亚博士讨论关于NAD与长寿的话题。

So they will infuse you directly with NAD into the vein.

因此他们会直接将 NAD 注入您的静脉中。

Those NAD infusions are pretty darn uncomfortable.

那些 NAD 注射舒服。

Paxton Aaronson, too, getting his third league assist here also in the NAD VC.

帕克森·阿伦森也在这里得了他在北美发展联赛中的助攻。

NAD, short for nicotinamide adenine dinucleotide, is a coenzyme that occurs naturally in human cells.

NAD， 即烟酰胺腺嘌呤二核苷酸的缩写，是一种天然存在于人体细胞中的辅酶。

And so these epigenetic modifications, together with low NAD, can cause these permanent changes.

因此，这些表观遗传修饰与NAD水平低下相结合，可能导致这些永久性变化。

I take NR and NMN in an effort to increase NAD.

我服用 NR 和 NMN 来努力增加 NAD。

But NAD has not been approved by the FDA.

然而，NAD尚未得美国食品药品监督管理局（FDA）的批准。

Researchers theorize that increasing levels of NAD could improve cellular function and give long COVID patients more energy.

研究人员推测，提高NAD水平可能改善细胞功能，并为长新冠患者提供更多能量。

And the pathway that we're going to spend some time on is the so-called NAD pathway.

我们将重点讨论的是所谓的NAD通路。

NR, NMN, NAD being the major players.

NR、NMN、NAD是其中的主要角色。

We've talked about NR and NMN and NAD and the NAD pathway.

我们已经讨论了 NR 和 NMN 以及 NAD 和 NAD 途径。

So you can be using veteran blue, increasing your NAD.

所以你可以使用美蓝，增加你的烟酰胺腺嘌呤二核苷酸。

NR and NMN are considered by many to be precursors to NAD.

许多人认为 NR 和 NMN 是 NAD 的前体。

So today we are going to discuss the so-called NAD pathway.

因此，今天我们将探讨所谓的NAD通路。

NR versus NMN versus direct infusions, or even orally taking NAD.

NR与NMN的比较，直接注射与口服NAD的差异。

So it's going to recycle NADH back to NAD by converting the pyruvate into lactate.

所以它会通过将丙酮酸转化为乳酸，把烟酰胺腺嘌呤二核苷酸还原酶（NADH）回收成烟酰胺腺嘌呤二核苷酸（NAD）。

So that's probably the biggest one, and by the way, that's sort of what brings us to the NAD story.

这可能是最重要的一点，顺便说一下，这也正是我们谈论NAD故事的缘由。