An important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

脏中种帮助调节钾重吸收或分泌重要激素叫醛固酮。

Another example is a tumor that produces excess aldosterone, which just like renin, leads to fluid retention.

个例子是肿瘤生长也会产生过多醛固酮，种类似于素物质，会导致液体积存。

The diagnosis of hyperaldosteronism is mainly done by measuring levels of renin and aldosterone.

醛固酮增多症诊断主要通过测定素与醛固酮水平来完成。

Secondary causes of hyperaldosteronism are usually due to excess aldosterone production in response to high levels of renin.

醛固酮增多症继发性原因通常是由于高水平素导致醛固酮生成过多。

High aldosterone is associated with increased inflammation, Chronic kidney disease, Osteoporosis, and cardiovascular disease.

高醛固酮水平会增加体内炎症，导致慢性病、骨质疏松症以及心血疾病。

So in this case aldosterone levels are high and renin levels are low in.

因此，在这种情况下，醛固酮水平较高，素水平较低。

Aldosterone has it's purpose, but it's not a hormone you want to regularly have high levels of.

醛固酮有其作用，但在人体中，这种荷水平不能太高。

Now, an important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

所以，脏中有种重要激素可以帮助调节钾重吸收和分泌，这就是醛固酮。

But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

但是，正如我之前提到，低盐饮食会导致 RAA 系统活跃。

As this study shows, a low salt diet increases aldosterone by more than 3 fold in healthy people.

这项研究显示，健康正常人采用低盐饮食，其体内醛固酮水平将增加 3 倍有余。

This suggests that people actually following the WHO guidelines are chronically raising their aldosterone.

也就是说，遵循世卫组织关于盐摄入量建议人们，他们体内醛固酮长期处于较高水平。

Aldosterone is part of a hormone family or axis which work together and are called the renin-angiotensin-aldosterone system.

醛固酮属于特定激素家族或激素轴部分，这些激素共同作用，被称为素-血紧张素-醛固酮系统。

So this is basically the adverse effects of aldosterone dysregulation, independent of just the blood pressure effects.

因此， 这基本上是醛固酮失调负面影响，独立于血压效应之外。

Other pathological conditions that cause increased aldosterone levels include compensated heart failure and cirrhosis.

其他导致醛固酮水平增加病理状况包括代偿期心衰和肝硬化。

Less aldosterone floating around in the blood causes the body to start dumping sodium from the blood into the urine.

血中醛固酮减少使得尿钠排出增多。

This taking up more space issue triggers another mechanism in our body that causes the hormone aldosterone to stop being released.

血容量增加触发机制造成醛固酮这激素停止释放。

Aldosterone increases sodium channels on the lumen side of the principal cell and sodium-potassium pumps on the basolateral side of the principal cells.

它增加主细胞腔面钠离子、钾离子通道和基底面钠-钾泵数量。

With these medications around, aldosterone can't exert its effects.

有了这些药物，醛固酮就无法发挥其作用了。

These drugs inhibit Angiotensin Converting Enzyme, hindering an important step in the RAA system resulting in lower aldosterone and lower blood pressure.

这种药物通过抑制血紧张素转化酶作用（RAA 系统关键作用之），以达到降低醛固酮水平及血压目。

Treatment of hyperaldosteronism is usually with potassium-sparing diuretics, especially spironolactone, which competitively binds to aldosterone receptors on the principal and alpha-intercalated cells.

醛固酮增多症治疗通常使用保钾利尿剂，尤其是螺内酯：其可竞争性结合主细胞及α-闰细胞上醛固酮受体。