The oxidation,displacement and esterification of aromatic amines,aromatic amides and organic boranes using sodium perborate as oxidizing agent were reviewed.
In the related "amide route" starting from 2-chloroisonicotinic acid, 41 ,a secondary amide directing group was used to facilitate the ortho lithiation of the pyridine 3-position.
To suppress the interference of amide groups in the amorphous phase,the film was placed in heavy water for 4 weeks for deuteration and the deuteration rate was determined.
A kind of monosubstituted squaric amide ——mono carbamoyl amide of squaric acid 3(MCASAQ) was prepared by the condensation of squaric acid (SQ) with urea or its derivatives in water.
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