This system begins with your liver releasing angiotensinogen, and, after a series of steps that you can read about in an endocrinology textbook, angiotensin I is produced.

该系统开始从肝释放血管紧张素原，经过一系列步骤（请参考内分泌相关教材）之后，I 型血管紧张素产生了。

Along the same lines, drugs that reduce the effect of aldosterone can also cause hyperkalemia, and these are drugs like renin inhibitors, ACE inhibitors, angiotensin II receptor antagonists, selective aldosterone blockers, and potassium-sparing diuretics.

同理，可以降低醛固酮效能药物也可以导致高钾血症，例如素抑制、ACE抑制、血管紧张素II拮抗、选择性醛固酮滞以及保钾利尿等。

Your kidneys cook up hormones like renin and angiotensin which help regulate levels of sodium and fluids in your body, and also help expand and constrict blood vessels.

你会分泌素和血管紧张素等荷尔蒙，这些荷尔蒙有助于调节内钠和液水平，也有助于扩张和收缩血管。

But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

但是，正如我之前提到，低盐饮食会导致 RAA 系统活跃。

Angiotensin recruits aldosterone to reabsorb salt and water, which adds volume to the blood.

素-血管紧张素系统会招募醛固酮以重吸收盐和水，从而增加血容量。

It's because most of the drugs out there, whether they're ACE inhibitors, what's called angiotensin receptor blockers, calcium channel antagonists, the main classes of drugs that treat high blood pressure aren't targeted toward restoration of nitric oxide.

这是因为目前大多数药物，无论是血管紧张素转换酶抑制、所谓血管紧张素滞，还是钙通道拮抗， 这些治疗高血压主要药物类别， 其目标并非恢复氮氧化物水平。

And then we decided to look at, are these neurons actually capable to transmit information from angiotensin.

于是我们决定探究，这些神经元是否真能够传递来自血管紧张素信息。

This is going to trigger the production of this hormone, angiotensin 2, along with its sidekick, aldosterone, which can stimulate sodium appetite.

这将触发这种激素——血管紧张素2生成，以及它搭档——醛固酮生成，后者可以刺激对钠需求。

[Maddy Junkins] And this suggests that they're detecting aldosterone and responding with sodium appetite, but they're not detecting angiotensin and responding with thirst.

这表明它们能够检测到醛固酮并产生对钠需求，但它们无法检测到血管紧张素并产生口渴反应。

[Elena Gracheva] So, despite that they're sensitive to angiotensin, they cannot transmit this information downstream to different brain regions.

却无法将这一信息传递至下游不同脑区。

[Elena Gracheva] The next step was to check if neurons that detect angiotensin, are they actually sensitive to this hormone?

下一步是检查检测血管紧张素神经元是否真对这种激素敏感？

And to our surprise, they doubled and tripled the concentration of angiotensin in the blood.

令我们惊讶是，它们使血液中血管紧张素浓度翻倍甚至增至三倍。