This system begins with your liver releasing angiotensinogen, and, after a series of steps that you can read about in an endocrinology textbook, angiotensin I is produced.

该系统开始从肝脏释放紧张原，经过一系（请参考内分泌相关教材）之后，I 型紧张产生了。

Along the same lines, drugs that reduce the effect of aldosterone can also cause hyperkalemia, and these are drugs like renin inhibitors, ACE inhibitors, angiotensin II receptor antagonists, selective aldosterone blockers, and potassium-sparing diuretics.

同理，可以降低醛固酮效能的药物也可以导致高钾症，例如肾抑制、ACE抑制、紧张II受体拮抗、选择性醛固酮受体阻滞以及保钾利尿等。

Your kidneys cook up hormones like renin and angiotensin which help regulate levels of sodium and fluids in your body, and also help expand and constrict blood vessels.

你的肾脏会分泌肾和紧张等荷尔蒙，这些荷尔蒙有助于调节体内钠和液体的水平，也有助于扩张和收缩。

But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

但是，正如我之前提到的，低盐饮食会导致 RAA 系统活跃。

Angiotensin recruits aldosterone to reabsorb salt and water, which adds volume to the blood.

肾-紧张系统会招募醛固酮以重吸收盐和水，从而增加容量。

It's because most of the drugs out there, whether they're ACE inhibitors, what's called angiotensin receptor blockers, calcium channel antagonists, the main classes of drugs that treat high blood pressure aren't targeted toward restoration of nitric oxide.

这是因为目前大多数药物，无论是紧张转换酶抑制、所谓的紧张受体阻滞，还是钙通道拮抗， 这些治疗高压的主要药物类别， 其目标并非恢复氮氧化物的水平。

And then we decided to look at, are these neurons actually capable to transmit information from angiotensin.

于是我们决定探究，这些神经元是否真的能够传递来自紧张的信息。

This is going to trigger the production of this hormone, angiotensin 2, along with its sidekick, aldosterone, which can stimulate sodium appetite.

这将触发这种激——紧张2的生成，以及它的搭档——醛固酮的生成，后者可以刺激对钠的需求。

[Maddy Junkins] And this suggests that they're detecting aldosterone and responding with sodium appetite, but they're not detecting angiotensin and responding with thirst.

这表明它们能够检测到醛固酮并产生对钠的需求，但它们无法检测到紧张并产生口渴反应。

[Elena Gracheva] So, despite that they're sensitive to angiotensin, they cannot transmit this information downstream to different brain regions.

却无法将这一信息传递至下游的不同脑区。

[Elena Gracheva] The next step was to check if neurons that detect angiotensin, are they actually sensitive to this hormone?

下一是检查检测紧张的神经元是否真的对这种激敏感？

And to our surprise, they doubled and tripled the concentration of angiotensin in the blood.

令我们惊讶的是，它们使液中紧张的浓度翻倍甚至增至三倍。