Ankylosing spondylitis, also called Bechterew disease, is part of a group of diseases called seronegative spondyloarthropathies.

强直性脊柱也称Bechterew病，是一旧称为“血清阴性脊柱关节病”的疾病中的一种。

Inflammation and pain from ankylosing spondylitis is usually treated with non-steroidal anti-inflammatory drugs like ibuprofen.

强直性脊柱的和疼痛通常采用如布洛芬等非甾体药来治疗。

Ankylosing spondylitis is a systemic inflammatory disease, so it can cause symptoms, like weight loss, fevers, and fatigue.

强直性脊柱是一种性的性疾病，因此能够引起，如体重减轻、发热和疲劳。

In ankylosing spondylitis there's chronic inflammation of the intervertebral joints and the facet joints of the spine.

患有强直性脊柱时，椎间盘和关节突关节内存在。

All right, as a quick recap, ankylosing spondylitis is an autoimmune process, associated with the HLA-B27 gene, which attacks vertebral joints.

好，简单回顾下：强直性脊柱是一种与HLA-B27基因有关的自免疫疾病，会导致脊柱关节受累。

Most individuals with ankylosing spondylitis have the gene HLA-B27, which is a gene that encodes for a specific type of MHC class I molecule.

许多强直性脊柱患者都携带HLA-B27基因，该基因能编码一种特定的MHC Ⅰ分子。

Ankylosing spondylitis can be diagnosed using MRI, where there's typically erosion and narrowing of the joint spaces early on, and joint fusion later on.

利用MRI可诊断强直性脊柱，病程早期通常可见关节腔的侵蚀和狭窄，晚期可见关节融合。

So ankylosing spondylitis is a chronic inflammatory disease that affects the vertebral joints and makes the spine really stiff, but can also cause inflammation in other parts of the body like the eyes and blood vessels.

因此，强直性脊柱是一种累及脊柱关节并使脊柱变得僵直的慢性性疾病；它也会累及体其他部位，如眼部和血管。

It can be congenital, meaning that the person is born with it, or acquired, usually due to degenerative disorders like ankylosing spondylitis, where the bones remodel causing intervertebral discs ossification, and the narrowing of the spinal canal.

它可能是先天性的，也就是说患者出生便有这种情况；或是获得性的，通常原因是退行性疾病，如强直性脊柱，导致骨重塑，引起椎间盘骨化，进而造成椎管狭窄。