Olizarsin is an N-acetylgalactosamine conjugated antisense oligonucleotide that targets the messenger RNA of apolipoprotein C3, which inhibits triglyceride clearance.
So researchers have figured out how to engineer these retrons, basically training them to produce very specific pieces of DNA called, get this, antisense cDNAs.
因此, 研究人员已经想出了如何设计这些逆转录素,基本上是训练它们产生非常特异性 DNA 片段,称为反义 cDNA。
So this antisense cDNA, it binds to the gene's RNA message and that basically blocks the cell from being able to produce the protein it was supposed to make.