CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所建立QSAR能有效地进行碳青霉烯化物MIC值预测和化物筛选,新药开发提供新参考和思路。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆也是一种多重耐药,如果产生β-内酰胺酶,可以用素、氨基糖苷类、氟喹诺酮类以及烯类药治疗;如果产生ESBL,可以只应用烯类进行治疗;如果产生烯酶,则应用多粘素、替加环素或磷素进行治疗。