CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所建立
QSAR模型能有效地进行碳青霉
MIC
预测和筛选，为这新药开发提供新参考和思路。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌也是一种多重耐药菌，如果产生β-内酰胺酶，可以
菌素、氨
糖苷类、
酮类以及碳青霉烯类药物治疗；如果产生ESBL，可以只应碳青霉烯类进行治疗；如果产生碳青霉烯酶，则应多粘菌素、替加环素或磷霉素进行治疗。
