Abstract: Pyrrolizidine alkaloids(PAs) are widely distributed in plantae.Many PAs are hepatotoxic,Lung toxicity(carcinogenesis),neurotoxic and cytotoxic.
In addition, only certain murine mAb isotypes hae been shown to effectiely bind to and actiate elements of the human immune system, thereby triggering cytotoxic effector functions10.
In the thymus, these precursor T-cells mature and express either CD4 on helper T-cells or CD8 on cytotoxic T-cells sometimes known as suppressor T cells.
Some T cells (T8 cells) are cytotoxic or killer cells; they act directly on cells bearing antigen (tumor cells and tissue transplanted from an organ donor).
They are well-known, powerful signals that promote NK cell survival, proliferation, making more NK cells, and importantly, their activation and cytotoxic function, their ability to kill target cells.
医学百科 The Medicine Book (Big Ideas Simply Explained)
This agent of chemical warfare was used to make mustard gas, which had been deployed to deadly effect in World War I. It is a cytotoxic compound, meaning that it is harmful to cells.