Four is absolutely excruciating the debilitating, incapacitating, just shut you down, just absolute sheer pain.

四级是绝对折磨人的，使人衰，丧失能力，让晕厥，纯粹的痛苦。

Shame can be crippling and debilitating.

羞愧会起到削作用。

For others, the effects may include debilitating cramps, bloating, migraines and depression.

对其他人来说，其影响可能包括使人虚的抽筋、腹胀、偏头痛和抑郁。

Thus, we might choose the risky joy of drinking, but the overall debilitating effects of doing so prevent us from truly immersing ourselves in the precious gift that the universe has given to us: Life.

因此，我可能会选择喝酒这种冒险的快乐，但这样做的整体衰影响会阻止我真正沉浸在宇宙给我的珍贵礼物中：生命。

That could then hit world markets dead on in ways that could really be debilitating.

这会给世界市场以致命一击，使世界市场更加。

Although OCD can be debilitating, these types of treatments offer hope that one day soon, everyone with the disorder will be able to find relief and take back control of their life.

管强迫症可能让人元气大伤，但这些治疗也带来希望，希望有一天，每名患者都能够找到救济并且拿回己生活的控制权。

It can be debilitating, and cleaning won't solve the problem.

它是很累人的，清洁并没有办法解决问题的根源。

You have to allow for the possibility that political philosophy may make you a worse citizen rather than a better one or at least a worse citizen before it makes you a better one, and that's because philosophy is a distancing, even debilitating activity.

须承认政治哲学可能使成为更糟的公民，而不是更优秀的，至少在让成为更优秀公民前，先让变糟，因为哲学使人疏离现实，甚至可能化行动力。

These symptoms are not debilitating, they're not permanent, they don't host permanent long-term damage, they typically fade once you move away from the activity.

这些症状既不会使人衰，也不是永久性的，更不会造成永久性的损害，只要停止这类活动，症状就会消失。

In every caregiver that we train, I see the triumphs and the struggles of my mother caring for my grandmother through a debilitating neurological condition.

从我培训的每一位护理人员身上，我看到了母亲在照顾患神经衰的祖母时所取得的成就和进行的抗争。

He urged MPs to come together to end what he described as this debilitating feud and vote for his deal today.

他敦促议员团结起来，结束这场折磨人的长期争执，并在今天投票支持他的协议。

Another study of Korean immigrants found the discrimination was linked to debilitating mental health effects.

另一个针对韩国移民的研究发现，歧视和削心理健康的影响有关。

If, for example, the heart attack drug carried a higher risk of a debilitating, but not life-threatening, side effect like migraines rather than cancer, our evaluation of whether that risk is worth taking might change.

假如，这个预防心脏病的药物只会产生使人虚，或是偏头痛等副作用，并非可致命的癌症，那我对此药的风险评估就会产生变化。

But the noise of it has grown deafening and debilitating in the past two years.

但是在过去的两年里，恐惧之声变得震耳欲聋，令人衰。

And that is these debilitating medical ailments. They have become known as the Havana Syndrome.

就是那些使人衰的医学疾病，众所周知的“哈瓦那综合症”。

These may have included the murders of at least four scientists, the infection of computers at enrichment facilities by a debilitating worm called Stuxnet and, in November, an explosion at a missile-testing site near the town of Bid Kaneh.

这类事件可能包括至少四起针对伊朗科学家的谋杀案，伊朗铀浓缩设施计算机受一种精心研制的名为“震网”的蠕虫病毒感染，以及去年11月在比得卡纳镇附近导弹试验基地的一起爆炸案。

Romanticized sadness often overlooks the debilitating aspects of clinical depression, such as constant feelings of hopelessness and worthlessness, lack of energy and motivation, sleep and appetite disturbances, and even suicidal thoughts and self-harm.

浪漫化的悲伤常常忽视临床抑郁的削性方面，如持续的绝望感和无价值感、缺乏精力和动力、睡眠和食欲障碍，甚至杀念头和残。

She's done just such an amazing job of taking what could have been very debilitating and really converting it into something that is, you know, a benefit not just to her, but to people around her who don't even know.

她做了一件非常了不起的工作：把本来可能非常衰的事物转化为一种益处——不仅对她有好处，而且对她周围不知情的人有好处。

And they include terrible things -- debilitating muscle and joint pain, gastrointestinal distress -- but now you're thinking, " Five percent, not very likely it's going to happen to me, I'll still take the drug."

这些副作用包括一些可怕的情况——肌无力，关节疼痛和肠胃不适 ——但可能觉得：“ 才5%的比例，不太可能发生在我身上，我还是会服用它。”

And recent research is also leading some scientists to believe that in certain cases, thalidomide could help with a number of debilitating diseases, including some forms of breast cancer.

近期研究也让一些科学家相信，在某些情况中萨力多胺可以帮助一些衰竭性疾病的治疗，如乳腺癌。