Prescribed medication is the next step if dietary modifications and vitamin B6 therapy with doxylamine are ineffective.

如果饮食疗法与联合应用维生素B6和抗敏安无，步就需要开方药。

"Mr.Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine," the office said in a short statement.

主要意经定论根据特征判断死亡意外，由于方药引起混合应中毒。