The growth,infiltration and metastasis of oncoma depend on tumor angiogenesis.Vascular endothelial growth factor(VEGF)is the most important irritant factor of angiogenesis.
Vascular endothelial growth factor(VEGF) is also named as vascular permeability factor(VPF),which is a powerful angiogenesis and vascular diosmosis promoter discovered at present.
Nicotine and other chemicals from the cigarette simultaneously cause constriction of blood vessels and damage their delicate endothelial lining, restricting blood flow.
Now, regardless of type, Kaposi's sarcoma is an endothelial cell neoplasm, so it causes vascular proliferation, resulting in dark or violaceous plaques.