First, they damage the RBC membrane, resulting in intramedullary hemolysis, or RBC breakdown in the bone marrow; or extravascular hemolysis, when RBCs are destroyed by macrophages in the spleen.

首先，它们会破坏膜，导致髓内（骨髓中分解）外（被脾脏的巨噬破坏）。

With extravascular hemolysis, we have macrophages eating up red blood cells more than normal and unconjugated bilirubin production is ramped up, which is conjugated by the liver and sent to the gallbladder.

外时，巨噬吞噬，较正常时更多，进而加速了非结合胆素的产生，非结合胆素在肝脏转变为结合胆素，并输送至胆囊。