He has been a disappointment to me, Mr. Holmes -- a grievous disappointment.

他使我很失望，福尔摩斯先生，真叫人伤心啊。

Grievous genetic diseases caused by point mutations are especially frustrating, because we often know the exact single-letter change that causes the disease and, in theory, could cure the disease.

由点突变引起的严重遗传性疾病尤其令人沮丧，因为我们通常知道引起该疾病的确切的单字母变化，并且理论上该疾病可以治愈。

We have before us an ordeal of the most grievous kind. We have before us many, many months of struggle and suffering.

我们所将面临的是一场极其严酷的考验，将是旷日持久的斗争和苦难。

Ah! sir, I do indeed. It is a grievous affair to my poor girls, you must confess. Not that I mean to find fault with you, for such things, I know, are all chance in this world.

“唉，先生，我的确是说到这方面。你得承认，这对于我可怜的女儿们真是件不幸的事。我并不想怪你，因为我也知道，世界上这一类的事完全靠运。

When a woman in such a situation, neither old, deaf, crazed, nor whimsical, takes upon herself to sob and soliloquize aloud there is something grievous the matter.

当一个女人像她那样不老、不聋、不疯也不怪，却声哭泣，自言自语，一定是在她身上发生了不幸的事。

Such training, along with improvements in care back home, mean that those who do suffer grievous injuries on the battlefield are more likely to survive.

这样的培训再配以家中的精心照料，将意味着那些在战争中经受到严重创伤的人，将更有活下来。

He and his colleagues have said and done all the right things, avoiding the grievous mistakes of Iraq.

他和他的同僚们已经说了所有该说的话，做了所有该做的事，避免了重蹈伊拉克的覆辙。

A new and most unpleasant system of menace had begun, and the intent appeared to be to do him grievous bodily harm.

一种新的、最令人不快的、有计划的威胁开始了，其动是要给他的身体造成严重的伤害。

We have before us an ordeal of the most grievous kind.

摆在我们面前的是最悲惨的考验。

It was as incomprehensible as it was mortifying and grievous.

这既令人费解，又令人心碎和痛苦。

An ordeal is a long and unpleasant experience, and grievous means very bad.

一场磨难是指长期且不愉快的经历，而严重则意味着非常糟糕。

The strife of the proud leads to bloodshed, and their abuse is grievous to hear.

骄傲之人的争斗导致流血，他们的欺凌行为令人痛心。

And wrongfully inflicting upon her grievous mental suffering.

并对她造成了严重的心理痛苦。

It's harder when someone really commits very, very grievous sins against you.

当有人真的对你犯下极其严重的罪行时，原谅就更难了。

To her what she had done would naturally seem a grievous sin.

对她来说，她所做的自是一种严重的罪过。

He came regularly once a week to tell me his grievous story.

他每周定期来一次， 告诉我他悲惨的故事。

This action, denounced at the time by our government as a grave breach of neutrality as well as a grievous injury to American citizens, led first to remonstrances and finally to repeated claims for damages done to American ships and goods.

这一行动当时被我国政府谴责为严重违反中立以及对美国公民的严重伤害，首先导致抗议，最后导致一再要求对美国船只和货物造成的损失提出索赔。

It was an excellent divine gift, that gave a deeper pathos to the need, the sin, the sorrow with which it was mingled, as the canker in a lily-white bud is more grievous to behold than in a common pot-herb.

这是一份绝妙的神圣礼物，它使人们对需要、罪恶和与之交织的悲伤产生更深的悲痛，就像百合花蕾上的溃疡病比普通盆栽药草上的溃疡病更严重。

Basil Williams, Beit Professor of Imperial History at Oxford, wrote in 1921: " with all his grievous faults, a great man, and that at the root of his  imperialism were qualities that have done good service to mankind" .

牛津帝国史贝伊特教授巴斯尔·威廉斯在1921年写道：“尽管他有诸多严重的缺点，但他仍是一个伟的人物，而且在他帝国主义的核心品质中，有许多对人类有益的东西。”

Often, still, that draught from the local brewery is sound and invigorating, but there are grievous exceptions, and no doubt the tendency is here, as in other things — a falling off, a carelessness, if not a calculating dishonesty.

通常情况下，来自当地啤酒厂的啤酒是健康的，令人振奋的，但也有严重的例外，毫无疑问，这种趋势是存在的，就像在其他事情上一样——摔倒，粗心意，如果不是精打细算的话。