Method Treatment of 8,9 anhydroerythromycin 6,9 hemiketal with iodine in the alkaline solution provided corresponding N monodemethylated 12 membered ring erythromycin derivative.

方法8,9脱水红霉素6,9半缩酮碱性溶剂反得到N去甲基十二元环红霉素衍生物。