Frequently affected organs include the liver, where the bacterial toxins damage liver sinusoids and hepatocytes, causing bilirubin to spill into the bloodstream - which clinically translates as jaundice.

肝脏常见的受累器官，菌释放的毒素破坏肝窦及肝胞，导致胆红素释放入血液循环，在临床上表现为黄疸。

Misfolded alpha-1 antitrypsin can aggregate and get stuck in the endoplasmic reticulum of the liver hepatocytes where it's made, causing some of those cells to die.

错误折叠的α-1抗胰蛋白酶可聚集并阻塞于肝胞内质网中，即α-1抗胰蛋白酶产生的地方，导致其中一部分肝胞死亡。

Well fibrosis is a process mediated by special cells called stellate cells, that sit between the sinusoid and hepatocyte, known as the perisinusoidal space.

纤维化的胞调控的；胞位于血窦和肝胞之间，即窦周间隙。

Like an eco-friendly treatment plant, the liver uses cells called hepatocytes to convert toxic waste products into this bitter greenish liquid.

就像一个环保的处理厂，肝脏用一种名叫肝胞的胞，来将有毒的废弃产品转化成这种绿色，苦涩的液体。

Whatever the case, as the hepatocytes die and the liver becomes dysfunctional, blood doesn't get filtered, and so it doesn't get the nitrogen-containing toxins filtered by the liver like it normally would.

不论原因如何，随着肝胞坏死，肝功失常，血液无法正常滤，因而肝脏无法正常滤含氮毒素。

Supplementing the deficient protein in the blood doesn't fix the liver problems, since they're caused by defective alpha-1 antitrypsin building up in the hepatocytes.

于肝病变缺陷α-1抗胰蛋白酶在肝胞中累积造成的，仅补充血液中缺乏的蛋白质不能解决肝脏问题。

Still, the question of how mitochondria, specifically in hepatocytes, become damaged remains mostly a mystery.

至于肝脏里的线粒体如何受损的，仍一个谜。

Here's a pretty basic layout of the basic functional unit of the liver, you've got the portal vein and hepatic artery that combine into a sinusoid, which then goes into the central vein, and these are all lined with hepatocytes.

这一个肝脏基本功能单位的简单示意图，你可以看到门静脉和肝动脉来的血液在血窦汇集，然后流入中央静脉，这些都与干胞相平行。

When the hepatocytes are injured though, they secrete paracrine factors that " activates" and changes the stellate cells.

然而，当肝胞受损时，肝胞分泌的“旁分泌因子”，可以激活并改变胞。

Ultimately the answer to this question is still unknown, what is known is that in patients with Reye's syndrome the mitochondria inside their liver cells, or hepatocytes, become damaged.

确切原因我们并不知晓，但我们知道瑞氏综合征患者的肝脏胞（也就肝胞）内存在线粒体损伤。