Obesity and metabolic syndrome are recognized as strong risk factors for hand OA, but also knee OA, where low-grade chronic inflammation and systemic metabolic alterations disrupt joint tissue homoeostasis.

肥胖和代征被认为是手部骨关节炎的强素，同时也是膝关节骨关节炎的素，在这些情况下，低级别的慢性炎症和全身代改变会扰乱关节组织的稳态。