In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal inolement.
In Giardia, proteins involved in iron-sulfur cluster assembly and protein folding appear closely related to mitochondrial homologs and localize to a relict mitosome (6,7).
And there is at least one transgenic strain of mice that if you get it to overexpress, a different SIRT, SIRT6, but again, these are homologs throughout the species.