Methods To observe the effect of emodin on delayed type hypersensitivity (DTH) induced by dinitrofluorobenzene (DNFB), mice were administered emodin by i.p.
Type II hypersensitivity, which produces antibodies against host tissue; and type III hypersensitivity, which is caused by the antigen-antibodies complex, is the cause of the tissue injury.
This is thought to be a type I or type IV hypersensitivity reaction, and is typically a response to a medication like NSAIDs, penicillin, and diuretics.
Myasthenia gravis is a type II hypersensitivity disorder where the body produces antibodies that most commonly target nicotinic acetylcholine receptors on the surface of muscle cells.
IgA nephropathy is therefore a type III hypersensitivity disorder, meaning that pathology and inflammation will happen at the site the immune complexes deposit, not where they are formed.
Since processing all the visual input we encounter quickly and correctly is an enormous computational effort for the brain, this kind of hypersensitivity might act as a useful shortcut.
The reason this happens is that in type 1 diabetes there is a type 4 hypersensitivity response or a cell-mediated immune response where a person's own T cells attack the pancreas.