Method Hepatic and renal functions,and tissue biopsy were measured in rats with therapeutic,toxic and lethiferous dose treatment after a period of time.

分别测定治疗剂量、中毒剂量、致死剂量组小鼠在用药肾功能,并进行组织病理学检查。

Take the experimental rats into 8 groups including 3 groups for therapeutic dose,3 groups for toxic dose and 2 groups for lethiferous dose, with 10 rats for each group and male and female for half.

将实验小鼠（幼年）分成8组，其中治疗剂量3组，中毒剂量3组，致死剂量2组，每组10只，雌雄各半。