Sandhoff results from a genetic mutation that reduces the body's supply of an enzyme, called hexosaminidase ("hex"), used by brain cells to metabolize excess fatty material called lipids.
由基因突变导致
山德霍夫氏病会减少体内
一种叫做己糖胺酶
供应,而脑细

来代谢过多
脂
。
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Peripheral dopa decarboxylase also exists, which can metabolize levodopa into dopamine before it gets through the blood brain barrier, and—via additional enzymes— metabolize it into other catecholamines like epinephrine, which can cause unwanted side effects like arrhythmias.
内还有外周多巴脱羧酶,可以在左旋多巴穿过血脑

将其转换为多巴胺;然后,通过其他酶将其转换为其他儿茶酚胺,如肾上腺素,它可以导致不良的副作用,如心律失常。