The introduction of the capacity to spread, this property called metastasis.

引入扩散能力，这一特性被称为。

The metastasis is there, it's spread, but the origin site, completely elusive.

发，病情扩散，但原发部位却完全无法确定。

Among 14 patients with baseline brain metastases (BM), capmatinib had an intracranial RR of 50%.

14 名基线脑 (BM) 患者中，卡马替尼的颅内 RR 为 50%。

Palliative radiotherapy Radiotherapy provides effective palliation of symptomatic advanced intrathoracic disease and metastases.

姑息性放疗 放疗可有效缓解有症状的晚期胸内疾病和瘤。

It took a village to help me study metastasis.

花了一个村庄来帮助我研究。

The hypoxic AT, orange, the one specialized for low oxygen, was completely absent in the lung metastases.

缺氧的AT（橙色），即专门适应低氧环境的细胞类型，肺灶中完全缺失。

But if there are any distant metastases, translating as M1, the tumor is considered stage IV regardless of T and N status.

但如果发了远端，即M1，那么不管T和N的亚分期如何，该肿瘤都将被认为是IV期。

It's a comprehensive pan-cancer human brain metastasis atlas.

这是一个全面的泛癌种人类脑瘤图谱。

And today, our focus is, well, it's on a really tough clinical challenge, brain metastases, or BRM.

今天，我们的重点是，嗯，一个非常棘手的临床挑战——脑瘤，或称BRM。

Through a process called metastasis a malignant tumor's cells will eventually break off, travel throughout the body, and begin forming tumors in other regions.

通过，恶性肿瘤的细胞最终会断裂，然后遍布全身，并开始其他区域形成肿瘤。

So high RI means big changes happen during metastasis.

因此，高的RI值意味着过程中发了巨大变化。

A high R.I. means the metastasis forced a huge remodeling of the local brain ecosystem.

较高的R.I.值意味着灶迫使局部脑态系统发了巨大的重塑。

Metastasis is a spread of cancer from a primary site to a distal site, through the circulatory or the lymphatic system.

是癌症通过循环系统或淋巴系统从原发部位扩散到远端部位。

What about metastasis of unknown primary, or MUP?

未知原发灶，即MUP的情况又如何呢？

He explained the process of metastasis, the spread of cancer from a primary tumour through lymph nodes to other sites in the body.

他阐述了的过程，即癌症从原发肿瘤通过淋巴结扩散至身体其他部位的现象。

Several prospective trials have demonstrated activity of first-line chemotherapy against NSCLC metastases, with RRs of 20- 50% for platinum-based regimens.

几项前瞻性试验证明一线化疗对 NSCLC 具有活性，铂类化疗方案的 RR 为 20-50%。

In addition to disease location, the chronology of metastasis emergence is also important, with synchronous lesions associated with poorer survival outcomes.

除了疾病部位外，出现的时间顺序也很重要，同步病变与较差的存结果相关。

Acute hemorrhage of a metastasis or compression of a nearby artery can also result in a stroke.

的急性出血或附近动脉受压也可能导致中风。

One relatively unique feature is that they metastasize through the cerebrospinal fluid in a process called drop metastasis where the tumor spreads to the base of the spine.

一个相对独有的特征是它们通过脑脊液发；这种方式称为下行，即肿瘤细胞播散至脊髓底部。

Direct evidence comparing SRS with surgery for patients who do not need urgent decompression but have a small number of resectable metastases is limited.

对于不需要紧急减压但有少量可切除瘤的患者，比较 SRS 与手术的直接证据有限。