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Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryon...

DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease.

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科学60秒-科学 2020年11月合集

As we age, some stretches of DNA get more methylated, and others less.

随着年龄的增长,一些DNA片段的甲基化程度会上升,而另一些则会下降。

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Osmosis-遗传

If the paternal imprinting center is mutated, the region gets methylated and those genes get turned off, meaning that both the maternal and paternal genes are silenced.

如果父源印记中心突变,基将被甲基化沉默,导致母源和父源基都处于沉默状态。

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经济学-科技

Newborns whose mothers suffered from depression while they were pregnant are known to have more highly methylated glucocorticoid-receptor genes than others.

新生儿的母亲若是在怀孕期间出现抑郁症状,他们皮质激素受体基的甲基化程度就会比其他新生儿更高。

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经济学-科技

The consequence is to inactivate the gene being methylated.

甲基化作用将使甲基化的基失去活性。

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Osmosis-遗传

If both copies of chromosome 15 were derived from the mother, that means all the prader willi genes are methylated and silenced, since there's no unsilenced paternal genes.

如果15号染色体的两条同源染色体都来自母方,就意味着所有的普拉德-威利基都被甲基化沉默,根本就没有父源基的表达。

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Osmosis-遗传

Translocations can disrupt SNRNP and move the small nucleolar RNA genes away from their imprinting center, causing them to get methylated and turned off.

SNRNP基易位会破坏小蛋白(SNRPN),并将仁小RNA基移出印记中心,导致这些基的甲基化沉默。

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Mind Pump: Raw Fitness Truth

So anytime I had a client who presented these symptoms, with tributavines, didn't work, I'd switch to methylated, and I'd say 50% of the time it did the trick.

此,每当遇到表现出这些症状的客户,在使用普通叶酸无效时, 我会改用活性叶酸,大约有一半的情况, 问题就这样解决了。

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TED-Ed(视频版)

In one famous experiment, when mother rats weren't attentive enough to their pups, genes in the babies that helped them manage stress were methylated and turned off.

在一个着名实验中, 当母鼠对幼崽的照顾不够周到时,幼崽体帮助它们应对压力的基会被甲基化并关闭。

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The Joe Rogan Experience

Take that with a methylated multivitamin and take that with an omega-3 fatty acid, and you have all the bases covered first thing in the morning.

早上第一件事就是服用甲基化复合维生素和Omega-3脂肪酸,这样你就涵盖了所有基础。

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The Joe Rogan Experience

But if you don't methylate that metal out of your body and you keep eating that same kind of fish, I mean, nobody got mercury poisoning from a single piece of tuna fish.

但如果你不能将体的金属甲基化排出, 并且继续吃同一种鱼,我是说, 没有会为吃了一块金枪鱼就汞中毒的。

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Mind Pump: Raw Fitness Truth

I once had a functional medicine practitioner that I worked with recommend to my client methylated B vitamins.

我曾与一位功能医学从业者合作,他建议我的客户服用甲基化B族维生素。

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