2.If Leptospira gets to the kidneys, it may infect the interstitium, causing interstitial nephritis, or it may cause an inflammatory reaction that damages the renal tubules, resulting in acute tubular necrosis.
3.So as a quick recap, intrarenal AKI is kidney injury caused by something within the kidneys themselves, which could be the tubules as in acute tubular necrosis, the glomerulus as in glomerulonephritis, or the interstitium as in acute interstitial nephritis.
4.Alright, finally we have damage to the kidney interstitium as a cause of intrarenal AKI, one key example being acute interstitial nephritis, which is inflammation of the interstitium over the course of days to weeks.