NG2-73 selectiely modulates receptors of the gamma-aminobutyric acid (GABA) neurotransmitter system and is one of seeral un partnered compounds in Neurogen's portfolio.
NG2-73是GABA
神
受体的选择性调节剂,本项目暂无其他合作开发伙伴。
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经
心理 In the central nervous system, nicotinic receptors are on pre-synaptic axon terminals of neurons, and when nicotine binds to them, it triggers the release of neurotransmitters like dopamine, acetylcholine, and glutamate, which is why it's considered an acetylcholine agonist.
在中枢
经系统中,烟碱受体分布于突触前
经元的轴突末端,当尼古丁与受体结合后,会触发多巴胺、乙酰胆碱、谷氨酸盐等
经递质的释放,因此尼古丁被认为是一种乙酰胆碱受体兴奋剂。
Within about 10 seconds, the bloodstream carries a stimulant called nicotine to the brain, triggering the release of dopamine and other neurotransmitters including endorphins that create the pleasurable sensations which make smoking highly addictive.
在大概十秒的范围内,血液携带一种叫做尼古丁的兴奋剂进入大脑,多巴胺和其他
经递质释放的触发,包括内啡肽,会通过制造愉快的感觉,使吸烟上瘾。
Excitatory neurotransmitters depolarize the postsynaptic neuron by making the inside of it more positive and bringing it closer to its action potential threshold, making it more likely to fire that message on to the next neuron.
兴奋性
经递质通过使突触后
经元内部更加积极并使其更接近其动作电位阈值来去极化突触后
经元,使其更有可能将该信息发送到下一个
经元。