Hydrochlorothiazide boosts calcium retention in the kidney and directly stimulates osteoblast differentiation, therefore decreasing mineral bone loss.

氢氯噻嗪促进肾脏中钙的直接刺激造骨细胞化，因此减少骨质流失。

Osteoclasts break down the unneeded mineral lattice using acids and enzymes so that osteoblasts can then add more material.

破骨细胞以酸和酵素酶 将无用的矿物晶格拆解这样就可以提供 更多原料给造骨细胞。

Now, for bones to grow and develop properly, special bone cells, called osteoblasts, are hard at work.

在骨正常的生长发育过程中，有种特殊的骨细胞，成骨细胞，起了至关重要的作用。

To build bone, osteoblasts secrete osteoid, which is an organic matrix made of type 1 collagen.

在构建骨的过程中，成骨细胞泌类骨质，它是种由1型胶原组成的有机质。

These collagen fibers are the framework for the osteoblasts' work.

这些胶原纤维为成骨细胞的工作构建了框架。

Osteoblasts then deposit calcium and phosphate crystals into the framework.

之后成骨细胞会往这个框架内积聚钙和磷酸盐结晶。

Bone mineralization is dependent on an enzyme called alkaline phosphatase - which increases in response to osteoblast activity.

骨的矿化依赖碱性磷酸酶；碱性磷酸酶响应成骨细胞活性而增加。

Cells called osteoblasts are like the construction workers.

被称为成骨细胞的细胞就像建筑工人样。

Picture a scaffold of collagen put together by these osteoblast construction workers.

想，这些成骨细胞建筑工人正在组装个由胶原蛋白构成的支架。

This means that osteoblasts don't have enough calcium and phosphate to deposit into the organic matrix.

这意味着成骨细胞没有足够的钙和磷可以沉积到骨有机质中。

Other benign tumors are osteoblastomas and osteoid osteomas, both of which arise from osteoblasts.

其他良性肿瘤包括成骨细胞瘤、骨样骨瘤，两者均起源于成骨细胞。

So an osteoblast in your bone becomes an osteocyte — ditto for chondroblasts becoming chondrocytes.

所以你骨骼中的成骨细胞就变成了个骨细胞。——软骨母细胞成为软骨细胞也是如此。

Putting physical stress on your bones by lifting weights or biking or running stimulates osteoblasts.

通过举重、骑自行车或跑步给骨骼施加物理压力可以刺激成骨细胞。

Eventually osteoblasts get activated and a process called ossification will start, which is when the fibrous tissue turns to bone.

最后成骨细胞活化，骨化过程启动，纤维组织最终转化为骨组织。

And finally we got an introduction to the process of bone remodeling, which is carried out by crews of osteocytes, osteoblasts, and osteoclasts.

最后，我们得到了骨骼重塑过程的介绍，这是由骨细胞、成骨细胞和破骨细胞团队进行的。

They're like the construction foremen of your bones, passing along commands to your skeleton's two main workhorses: the osteoblasts and the osteoclasts.

它们就像你骨骼的建筑工头，将命令传递给你骨骼的两个主要主力：成骨细胞和破骨细胞。

Osteosarcomas arise from osteoblasts of different sizes - called pleomorphic - and these cells produce too much osteoid tissue.

骨肉瘤起源于大小不同的成骨细胞（多形性）；这些细胞会产生过多的类骨组织。

Importantly, ectopic expression of c-Fos in H2-c-fosLTR transgenic mice drives osteoblast and chondrocyte proliferation resulting in osteosarcoma and chondrogenic sarcoma.

重要的是，H2-c-fosLTR转基因小鼠中c-Fos的异位表达驱动了成骨细胞和软骨细胞的增殖，导致了成骨肉瘤和软骨肉瘤的形成。

Now, even though parathyroid hormone stimulates bone resorption, it's been found that intermittent injections with teriparatide activates osteoblasts more than osteoclasts, therefore increasing bone formation.

其实，即使甲状旁腺激素刺激骨吸收，研究发现间歇性注射特立帕肽激活了更多造骨细胞而非破骨细胞，从而增强骨生长。

But before they auto-terminate, they use the hormone hotline to call over the osteoblasts, who come in and begin rebuilding the bone.

但是在它们自动终止之前，它们使用激素热线呼叫成骨细胞，成骨细胞进来开始重建骨骼。