The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白酰化酰化由对功能抗的蛋白酶——组蛋白酰基转移酶组蛋白酰化酶负责。