Over time, if enough of the neurons die in the caudate and putamen, which together form the dorsal striatum, then it can cause actual loss of brain tissue volume in that area and expansion of the lateral ventricles.

随着推移，如果由尾状核和壳核构成背侧纹状体死亡神经元细胞越来越多，会引起该区域减少，进而导致侧室扩大。