Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.

同时利所成的化物3，14，16为模板，对它们的3位羧基进行了酯化反成了4个喹诺酮酯类化物：化物22—25。

Difloxacin is the fluorinated quinolone approved for use in veterinary only. compared to ciprofloxacin,it provided with better pharmacokinetical and pharmacodynamical feature.

二氟沙星属于专药物，并且有优于环丙沙星的药动学特征，具有良好的前景。