Difloxacin is the fluorinated quinolone approved for use in veterinary only. compared to ciprofloxacin,it provided with better pharmacokinetical and pharmacodynamical feature.

二氟属于兽医专药物，并且有优于环丙药动学特征，有良好应。

Finally, we gained four esterifiable quinolone analogues (compounds 22 to 25) by modifying the structures of compound 3, 14 and 16 on 3 position.

同时利所合成化合物3，14，16为模板，对它们3位羧基进行了酯化反应合成了4个喹诺酮酯类化合物：化合物22—25。