Specifically, HHV-8 causes Kaposi's sarcoma, a type of cancer usually seen in individuals with AIDS.

具体来说，HHV-8能引起卡波西肉瘤，一种常见于艾滋病患者的癌症。

Diagnosis of Kaposi's sarcoma requires a biopsy of the lesions.

卡波西肉瘤的诊断需要对病灶进行组织活检。

I remember a young woman who had a sarcoma, and she was 23 years old and had four young children.

我记得一个年轻的女人得了肉瘤，她23岁，有四个孩子。

Ewing sarcoma is thought to arise from neuroectodermal cells, and which look like small, round, blue cells on microscopy.

尤因肉瘤被认为源于胚层细胞；它们在显微镜下呈现为小的、圆形的蓝色细胞。

So, classic Kaposi's sarcoma usually affects older males, it's slow growing and it usually affects the legs.

典型卡波西肉瘤通常累及老年男，其生长缓慢，一般侵染腿部。

Endemic Kaposi's sarcoma occurs in young adult males who live in Africa and can be more aggressive.

非洲型卡波西肉瘤常见于非洲年轻成年男中，且更具侵袭。

Finally, immunosuppression therapy-related Kaposi's sarcoma affects the skin, and it usually develops following organ transplantation.

后，免疫抑制相关型卡波西肉瘤侵染的是皮肤，通常在器官移植后出现。

Treatment is mainly aimed to stop the progression of Kaposi's sarcoma, as the disease is not curable.

治疗旨在阻止卡波西肉瘤的病程进展，该疾病无法治愈。

Kate Granger, a 32-year-old doctor suffering from an incurable form of sarcoma, has very strong ambitions for her last hours.

32岁的凯特·格兰格是一位医生，却身患无法治愈的恶肿瘤，她对自己剩下的时间有巨大的野心。

Another type of malignant bone tumor is Ewing's sarcoma, which is also common in adolescents, typically between the age of 10 to 20 years.

另一种恶骨肿瘤是尤因肉瘤，通常见于10至20岁之间的青少年。

Ewing's sarcoma can affect a number of different bones, but most commonly affects the femur and the sacrum.

尤因氏肉瘤可累及许多不同的骨骼，但常见的是股骨与骶骨。

Epidemic Kaposi's sarcoma is associated with AIDS and can affect many body parts such as skin, mouth, GI tract or lungs.

艾滋病型卡波西肉瘤与艾滋病相关，会侵染身体多个器官，比如皮肤、口腔、胃肠道或者肺部。

This protein causes defects in the differentiation process of human mesenchymal stem cell and neuroectodermal cells, resulting in Ewing sarcoma tumor cells.

该蛋白在间充质干细胞、胚层细胞分化过程中引起缺陷，产生尤因肉瘤肿瘤细胞。

Kaposi's sarcoma affects most commonly the skin but it can also affect mouth, GI tract and lungs.

卡波西肉瘤主要侵染皮肤，但也可以侵染口腔、胃肠道与肺部。

Ewing sarcoma is associated with chromosomal mutations, specifically a translocation between the EWSR1 gene on chromosome 22 and FLI1 gene on chromosome 11.

尤因肉瘤与染色体突变有关，特别是22号染色体上的EWSR1基因和11号染色体上的FLI1基因之间的易位。

In Ewing sarcoma, X-ray shows lytic bone lesions referred to as onion skin appearance, because the periosteum looks like a sliced onion bulb.

在尤因肉瘤中，X线显示溶骨病变，称为“洋葱皮样”观，因为骨膜看起来像一个切开的洋葱球。

Now, regardless of type, Kaposi's sarcoma is an endothelial cell neoplasm, so it causes vascular proliferation, resulting in dark or violaceous plaques.

无论何种类型的卡波西肉瘤，都是一种内皮细胞瘤，因此它会引起的增殖，导致黑色或紫色斑块。

Osteosarcoma is linked to RB1 and TP53 genes mutations, while Ewing sarcoma is thought to arise when there are EWSR1, and FLI1 genes mutation.

骨肉瘤与RB1和TP53基因突变有关，尤因肉瘤被认为源于EWSR1和FLI1基因的易位。

Other conditions include certain tumors and malignancies like Kaposi sarcoma which causes lesions on the skin and other soft tissues, and primary lymphoma of the brain.

其它还包括某些恶肿瘤，如引起皮肤和其它软组织损伤的卡波西肉瘤及脑组织原发淋巴瘤。

Specifically, HHV-8 causes a disease called Kaposi's sarcoma which is classified into 4 types depending on the clinical circumstances in which it develops: classic, endemic, epidemic and immunosuppression therapy-related.

具体来说，HHV-8会引起一种叫做“卡波西肉瘤”的疾病，根据其临床表现，卡波西肉瘤可分为4种类型：典型、非洲型、艾滋病型与免疫抑制相关型。