So focal segmental glomerulosclerosis is a type of nephrotic syndrome, that's helpful, but why does the glomerulus develop segmental sclerosis in the first place?
Alright so on histology, there'll be segmental sclerosis and hyalinosis of the glomeruli, and under electron microscope, there's effacement of the foot processes of the podocytes.
Segmental means that only a segment, or part of the glomeruli is affected, and focal means that among all those glomeruli in the kidney, only some are affected.
Alright, so as a quick recap, focal segmental glomerulosclerosis is a nephrotic syndrome characterized by sclerosis and hyalinosis in some, but not all, glomeruli, and usually only affects part of the glomeruli that it affects.
And again the carriage sped along the road, the lady's eyes resting on the segmental hill, the blue trees that muffled it, and the column that formed its apex, till they were out of sight.