As this fibrotic tissue builds up, it starts to compress the central veins and sinusoids.

堆积在一起的纤维组织会挤压中央静脉和血。

Well fibrosis is a process mediated by special cells called stellate cells, that sit between the sinusoid and hepatocyte, known as the perisinusoidal space.

纤维化的过程是细胞调控的；细胞位于血和细胞之，即周隙。

Frequently affected organs include the liver, where the bacterial toxins damage liver sinusoids and hepatocytes, causing bilirubin to spill into the bloodstream - which clinically translates as jaundice.

脏是常见的受累器官，细菌释放的毒素破及细胞，导致胆红素释放入血液循环，在临床上表现为黄疸。

As the central veins and sinusoids become compressed and push on the fluid inside, their pressure starts to build up, leading to intrasinusoidal (or portal) hypertension, which is this higher pressure in the portal veins.

中央静脉和血的受压导致它们中的液体也受到挤压，导致门静脉高压，即门静脉的压力升高。

Here's a pretty basic layout of the basic functional unit of the liver, you've got the portal vein and hepatic artery that combine into a sinusoid, which then goes into the central vein, and these are all lined with hepatocytes.

这是一个脏基本功能单位的简单示意图，你可以看到门静脉和动脉来的血液在血汇集，然后流入中央静脉，这些都与干细胞相平行。