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This paper summarized the research advance in the live attenuated vaccine,sporozoite vaccine and DNA vaccine.

减毒活和核酸研究进展。

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These combine and grow to become the immature form of the parasite, called a sporozoite.

这些结合并生长成为寄生虫的未成熟形式,称为孢子

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Then, when that mosquito bites another human, the sporozoites are injected too, and travel to the liver to hunker down, grow, and multiply.

, 当这只蚊子咬另一人类时, 子孢子也会被注入,并前往肝脏潜、生长和繁殖。

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Knocking out just three of the 5000 genes in the P. falciparum genome can prevent sporozoites from maturing and reproducing, so they can’t infect the bloodstream.

敲除恶性疟原虫基因组中的5000基因中的仅仅可以阻止子孢子成熟和繁殖,从而无法感染血液。

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Each sporozoite produces as many as 30,000 mature parasite cells called merozoites, which spread through the bloodstream, burrow into red blood cells, and cause a full-blown infection.

孢子可以产生多达30000成熟的寄生虫细胞, 称为裂殖子,这些裂殖子会通过血液扩散, 钻入红血细胞, 并引发全面感染。

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They infected mosquitoes with the genetically-engineered sporozoites and let them snack on the volunteers’ forearms. And none of the people in the trial developed malaria, so that’s good!

他们让蚊子感染了基因工程改造过的子孢子,并让蚊子叮咬志愿者的前臂。试验中没有人患上疟疾,这很好!

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