A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.
从
二酮的转化产生菌偶发分枝杆菌MF2出发,经紫外诱变结合平板筛选,
得一株主要转化生产睾酮的突变株TS-N-121。
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Benjamin Nettersheim, a geobiologist at the University of Bremen in Germany, Jochen Brocks, a palaeobiogeochemist at the Australian National University in Canberra, and their colleagues decided to focus on short-lived molecules that modern eukaryotes make while synthesizing sterols.
德国不莱梅
学的地球生物学家本杰明·内特谢姆、澳
利亚国立
学堪培拉分校的古生物地球化学家约翰·布洛克斯及其同事

重点放在现代真核生物合成类固醇时产生的短寿命分子上。




