Protein C or S deficiency is commonly asymptomatic, but symptoms arise when a venous thromboembolism develops.

蛋白C和S缺乏一般无临床状，当血栓栓时可出现状。

Symptoms of venous thromboembolism include pain similar to a muscle cramp, and swelling in the affected leg.

脉血栓栓的状包括类似肌肉痉挛的疼痛以及侧腿部肿胀。

Most people present with venous thromboembolism, where a blood clot of the leg veins or lung circulation is most common.

大部分会出现脉血栓栓，最常见的是在腿部脉及肺循环中形成血栓。

Initial treatment of venous thromboembolisms is the same as it would be for patients with normal protein C and protein S levels.

对脉血栓栓的初步治疗，与对拥有正常水平蛋白C和S的治疗是一样的。

A deep vein thrombosis can also send off a thromboembolism to the lungs which can cause a sudden pulmonary embolism which can be fatal.

深脉血栓也可能脱落血栓栓子；其到达肺部可导致致命的肺栓。

The major source of thromboembolism and stroke in non-valvular AFib is formation of thrombus in the left atrial appendage where flow is relatively stagnant.

膜性房颤中，血栓栓和卒中的主要来源是左心耳内血栓的形成，此处血流相对滞缓。

Protein C or protein S deficiency is also sometimes suspected when a venous thromboembolism develops in an unusual site like the portal, mesenteric, or cerebral veins.

当脉血栓栓出现在不常见的部位时，也要怀疑蛋白C或蛋白S缺乏，比如门脉、肠系膜脉或脑部脉。

Another UK study published last year found incidences of and deaths from thromboembolism doubled in the first six months of the pandemic compared to rates seen in the years prior.

去年发表的另一项英国研究发现，与前几年相比，在大流行的前六个月，血栓栓的发病率和死亡率翻了一番。

Protein C or S deficiency is suspected in people with a strong family history of coagulation disorders, especially those who suffer from recurrent venous thromboembolisms and experience their first thrombotic event before age fifty.

有明显凝血功能障碍家族史的可怀疑蛋白C或蛋白S缺乏，尤其是反复出现脉血栓栓，且于50岁之前发生第一次栓的。

A more serious presentation is neonatal purpura fulminans, which is when a newborn with protein C or S deficiency suffers massive arterial and venous thromboembolisms with hemorrhagic skin necrosis.

更严重的并发是新生儿暴发性紫癜，即有蛋白C和S缺乏的新生儿出现大量动脉血栓栓及出血性皮肤坏死。