Normally, the liver and kidneys produce a tiny hormone called thrombopoietin which binds to hematopoietic cell receptors.
正常情况下,肝脏和肾脏会合成一种叫做促血小板成素的激素,可以与造血胞受体结合。
Cells can also develop mutations in the thrombopoietin receptor, MPL, or in the chaperone protein, Calreticulin or CalR.
胞内的促血小板成素受体(MPL)或伴侣蛋白/钙网蛋白(CalR)也可以变。
Now, when there's a genetic mutation in CalR, the signalling pathway remains active all the time, and that means that platelets keep getting produced even in the absence of thrombopoietin.
在CalR基因变后,信号通路处于持续激活状态,这就意味着即使没有促血小板成素,血小板也会持续成。
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