Furfuryl propionate was synthesized from furfuryl alcohol and propionyl chloride using hexahydropyridine as catalyst and anhydrous sodium bicarbonate as acid-caputor.
Synthesis of isoamyl formate, isoamyl acetate, isoamyl propionate, isoamyl butyrate, isoamyl isobutyrate and isoamyl isovalerate by catalysis of hydrated ferric chloride are reported.
Glucose and heme are the treatments for acute intermittent porphyria as they inhibit aminolevulinic acid synthase, the first enzyme involved in heme synthesis.
Lead poisoning has also been shown to denature enzymes important in heme synthesis, like Delta aminolevulinate dehydratase and ferrochelatase, which are important for heme synthesis.
Aminolevulinic acid, in particular, is the most likely culprit since it could cross the blood brain barrier and affect the central, autonomic, and peripheral nervous systems.
And mice that were treated to proprionate, which was delivered via teeny tiny enemas to mimic its release by gut bacteria, similarly extended their treadmill time.