In rare cases, essential thrombocythemia can develop into myelofibrosis and acute leukemia.

少数原发性血小板增症案例会发展为骨髓纤维化或急性白血病。

All that being said, in situations where somebody produces too much aldosterone, like primary hyperaldosteronism, then there's more potassium secretion by the principal cells and excreted, and therefore less potassium is retained, leading to hypokalemia.

说了这么，在某人产生了太醛固酮下，比如原发性醛固酮增症，钾被主细胞分泌并排泄，这意味着少钾被保留，导致了低钾血症。

The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it's not really clear why this happens.

最常见原发性病因称为发性醛固酮增症：这是由于球状带分泌醛固酮细胞数量增加，但目前尚不清楚为什么会发生这种。

Hyperaldosteronism can happen due to primary causes which is where the adrenal gland itself is responsible for the excess production of aldosterone.

醛固酮增症可以是原发性，即肾上腺本身产生了过量醛固酮。

But more commonly, essential thrombocythemia is usually found unintentionally when elevated platelet levels are found on a routine complete blood count.

但原发性血小板增症常常是做常规全血细胞计数时发现血小板增，而被无意发现。

Treatment of essential thrombocythemia depends on risk of blood clots.

原发性血小板增症治疗取决于血栓形成风险。

Now, some individuals with essential thrombocythemia can have symptoms like fatigue, headache, dizziness, nausea, tinnitus or ringing in the ears, and numbness in the hands and feet.

有些原发性血小板增症患者，会有疲乏、头痛、晕眩、恶心、耳鸣（耳朵里有声音）以及手足麻木等症状。

So I think where I'm looking at into the future is say you get somebody with new onset hypertension or prehypertension, perform aldosterone read and profiling, identify those individuals as subclinical PA.

所以我认为未来我关注方向是， 比如遇到新发高血压或前期高血压患者，进行醛固酮检测和分析，识别出那些亚临床原发性醛固酮增症个体。

So as Greg mentioned earlier, so in this study found in normal population from the era using the immunoassay to be 12 and a half, so definitely lower for typical threshold for diagnosis of PA.

正如格雷格先前所提， 本研究在正常人群中采用免疫检测法得出数值为12.5，这显然低于诊断原发性醛固酮增症（PA）常规阈值。

And so our hypothesis was that independent of blood pressure, subclinical forms of primary aldosteronism would be associated with adverse cardiovascular events such as heart attack, stroke, heart failure, cardiovascular death.

因此， 我们假设是， 无论血压水平如何，原发性醛固酮增症亚临床形式都与不良心血管事件相关，如心脏病发作、中风、心力衰竭及心血管死亡。

And now let's move to that featured discussion about primary aldosteronism.

现在，让我们转向关于原发性醛固酮增症专题讨论。