A method for simultaneous separation and determination of two coumarins,dicumarol and cyclocoumarol,in cosmetics by HPLC-diode-array detector(DAD) was developed.
In the group of dicoumarol plus doxorubicin, serum ALT, LDH, CK activities were significantly increased as compared with that of doxorubicin group alone, and liver MDA content was also increased.