"We've become completely and utterly desensitise to the fact that breeding these deformed, disabled, disease-prone animals is either shocking or abnormal."
At this time your mind will be filled with such words as helpless, vacuous, choiceless, powerless.Such being the case, your only strategy is attention distracting.
However, a minority partially assume a gender that contradicts their physical sex ( transvestism ), and for an even smaller minority such an inversion is complete ( transsexualism ).
Say your boss wants a page to have a zappy marketing title you'd rather not have, because it doesn't exactly describe what's on the page, and pushes your most important keyword to the second heading.