Not all thermonuclear weapons yield as much power as Tsar Bomba, but even lesser bombs, like the United States B-41, can bring unimaginable destruction.
As black holes lose mass, they emit particles and energy faster, so each time one evaporates completely it'll emit a flare of light like a small bomb going off.
So that was pretty cool because, you know, we kind of converted our innocent little imaging agent into a little bomb that we put on a cancer cell and blow it up.