There is actually a new drug approved for, I believe it's approved for recurrent vulvovaginal candidiasis that just got approved a couple of years ago.
At this point, certain conditions start to develop that are said to be " AIDS-defining" , such as recurrent bacterial pneumonia, pneumocystis pneumonia, and fungal infections like candidiasis of the esophagus.
In one of his classic texts, he describes thrush, like oral thrush is what I'm referring to, particularly in people who are already sick or in poor health.
But even recurrent vulvovaginal candidiasis affects an estimated 138 million people with a vagina every year worldwide, and it's on the rise, and estimated to hit close to 160 million by 2030.